Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30672130 | 0.81 | MERTK (0.45) | MKNK1MKNK2MERTKBTK | |
| SCHEMBL21776508 | 0.78 | AXL (0.51) | MERTK | |
| Hydrochloric Acid SCHEMBL29812561 | 0.77 | AXL (0.50) | MERTK | |
| SCHEMBL30672131 | 0.76 | TGFBR1 (0.44) | CAPN1BTKRETRXFP1 | |
| SCHEMBL28019336 | 0.70 | MKNK1 (0.58) | MKNK1MKNK2PKN1PKN2CYP1A2 | |
| SCHEMBL30514275 | 0.70 | BCAT2 (0.67) | MKNK1MKNK2PKN1PKN2F7 | |
| SCHEMBL31227976 | 0.70 | BCAT2 (0.67) | MKNK1MKNK2PKN1PKN2F7 | |
| SCHEMBL167082 | 0.70 | BCAT2 (0.67) | MKNK1MKNK2PKN1PKN2F7 | |
| SCHEMBL29626183 | 0.69 | KMT2A (0.35) | KMT2A | |
| Hydrochloric Acid SCHEMBL30165666 | 0.69 | BCAT2 (0.65) | MKNK1MKNK2PKN1PKN2F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | claimed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |