Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29812561 | 0.70 | AXL (0.50) | — | |
| SCHEMBL29811977 | 0.70 | IRAK4 (0.35) | IRAK4KDM4EPARP1KEAP1NFE2L2 | |
| SCHEMBL29626235 | 0.70 | PIM1 (0.33) | KMT2APOLBL3MBTL1 | |
| SCHEMBL30672131 | 0.69 | TGFBR1 (0.44) | PARP1PARP2ADRA1D | |
| SCHEMBL29626199 | 0.69 | MKNK1 (0.48) | KMT2A | |
| Hydrochloric Acid SCHEMBL29812364 | 0.69 | IRAK4 (0.34) | IRAK4KDM4EPARP1KEAP1NFE2L2 | |
| SCHEMBL23846561 | 0.68 | IRAK4 (0.33) | IRAK4KDM4EL3MBTL1ADRA1D | |
| SCHEMBL29720954 | 0.64 | PIM1 (0.33) | KMT2AIRAK4KDM4EADRA1D | |
| SCHEMBL16644420 | 0.63 | DGAT1 (0.46) | KMT2AMEN1KDM4EPARP1HTT | |
| SCHEMBL28838264 | 0.62 | ADRA1D (0.36) | KMT2AIRAK4PARP1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |