SCHEMBL29626417

SCHEMBL29626417

C[Si](C)(C)c1c(OS(=O)(=O)C(F)(F)F)ccc2ccccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
KDM4E B2RXH2 2/20 0.36
SLC2A1 P11166 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HSD17B10 Q99714 1/20 0.36
NCEH1 Q6PIU2 2/20 0.35
L3MBTL1 Q9Y468 3/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP3A4 P08684 1/20 0.34
HSD11B1 P28845 1/20 0.34
DRD2 P14416 3/20 0.33
DRD3 P35462 3/20 0.33
DRD4 P21917 2/20 0.33
GAA P10253 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15565613 1.00 MAPT (0.38) MAPTCYP1A2CYP2C9CYP2C19KDM4E
SCHEMBL20563667 0.87 NCEH1 (0.47) MAPTCYP1A2CYP2C9CYP2C19KDM4E
SCHEMBL29560409 0.80 MAPT (0.49) MAPTCYP1A2CYP2C9CYP2C19SLC2A1
SCHEMBL635407 0.80 MAPT (0.49) MAPTCYP1A2CYP2C9CYP2C19SLC2A1
SCHEMBL30706241 0.80 DRD2 (0.42) DRD2DRD3DRD4DRD1DRD5
SCHEMBL20563974 0.79 MAPT (0.37) MAPTCYP1A2CYP2C9CYP2C19KDM4E
SCHEMBL7709361 0.79 MAPT (0.37) MAPTCYP1A2CYP2C9CYP2C19KDM4E
SCHEMBL31375043 0.78 MAPT (0.46) MAPTCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL17048014 0.78 DRD2 (0.39) KDM4EALDH1A1DRD2DRD3DRD4
SCHEMBL15565904 0.78 DRD2 (0.32) KDM4EHSD11B1DRD2DRD3DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114423754-A Antiviral agents and uses thereof 格里菲斯大学 2022-04-29 CN disclosed