Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.52 |
| ▸ | NPC1 | O15118 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15348832 | 0.81 | L3MBTL1 (0.51) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL28610054 | 0.81 | L3MBTL1 (0.51) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL18191549 | 0.79 | HPGD (0.60) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL30848604 | 0.79 | L3MBTL1 (0.49) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL3717251 | 0.79 | L3MBTL1 (0.49) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL4968237 | 0.79 | L3MBTL1 (0.49) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL12230264 | 0.78 | PIK3C3 (0.47) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL29626665 | 0.78 | CBLB (0.61) | — | |
| SCHEMBL9292806 | 0.77 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL21695722 | 0.77 | MAPK1 (0.44) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |