Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.41 |
| ▸ | DTYMK | P23919 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29626721 | 0.91 | NPC1 (0.48) | NPC1POLBDDB1CRBNSCD5 | |
| SCHEMBL20721877 | 0.84 | OTUD7B (0.57) | POLBDDB1CRBNSCD5DTYMK | |
| SCHEMBL22944644 | 0.81 | GPR119 (0.43) | NPC1POLBDDB1CRBNSCD5 | |
| SCHEMBL29626805 | 0.80 | NPC1 (0.47) | NPC1KCNH2OTUD7B | |
| SCHEMBL22980435 | 0.80 | POLB (0.47) | POLBDDB1CRBNSCD5DTYMK | |
| SCHEMBL10286651 | 0.79 | HSD11B1 (0.46) | POLBSCD5DTYMKCYP11B2GPR119 | |
| SCHEMBL29416284 | 0.78 | KCNH2 (0.61) | POLBDTYMKGPR119KCNH2AKT1 | |
| SCHEMBL12180668 | 0.77 | POLB (0.43) | POLBDDB1CRBNSCD5DTYMK | |
| SCHEMBL2588219 | 0.77 | POLB (0.43) | POLBDDB1CRBNSCD5DTYMK | |
| SCHEMBL22300223 | 0.76 | IDO1 (0.40) | CRBNSCD5GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |