Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 7/20 | 0.63 |
| ▸ | IDO1 | P14902 | 9/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CCNH | P51946 | 1/20 | 0.50 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | KDM5C | P41229 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.49 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741907 | 1.00 | METAP2 (0.63) | METAP2IDO1KEAP1SIRT3CCNT1 | |
| SCHEMBL28741959 | 0.81 | METAP2 (0.61) | METAP2IDO1KEAP1SIRT3XDH | |
| SCHEMBL4318387 | 0.80 | METAP2 (0.55) | METAP2IDO1KEAP1SIRT3KDM4E | |
| SCHEMBL28741748 | 0.80 | IDO1 (0.58) | METAP2IDO1KEAP1SIRT3CDK8 | |
| SCHEMBL3663278 | 0.79 | CCNT1 (0.52) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL31422694 | 0.78 | PARP1 (0.64) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL2431097 | 0.78 | PARP1 (0.64) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL5004755 | 0.77 | METAP2 (1.00) | METAP2IDO1KEAP1SIRT3KDM4E | |
| SCHEMBL28303592 | 0.77 | CCNT1 (0.50) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL6999225 | 0.76 | DHODH (0.63) | CCNT1CCND1CCNCCDK8CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |