Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 9/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741907 | 0.80 | METAP2 (0.63) | METAP2IDO1KEAP1SIRT3XDH | |
| SCHEMBL29626795 | 0.80 | METAP2 (0.63) | METAP2IDO1KEAP1SIRT3XDH | |
| SCHEMBL28741748 | 0.74 | IDO1 (0.58) | METAP2IDO1KEAP1SIRT3XDH | |
| SCHEMBL30545116 | 0.73 | MEN1 (0.70) | MEN1KMT2A | |
| SCHEMBL22557901 | 0.73 | MEN1 (0.70) | MEN1KMT2A | |
| SCHEMBL4326155 | 0.72 | KMT2A (0.54) | MEN1KMT2AKDM4E | |
| SCHEMBL5004755 | 0.72 | METAP2 (1.00) | METAP2MEN1KMT2AIDO1KEAP1 | |
| SCHEMBL4328141 | 0.71 | KMT2A (0.53) | MEN1KMT2AKEAP1KDM4E | |
| SCHEMBL4456350 | 0.70 | XDH (0.62) | METAP2KMT2AIDO1KEAP1SIRT3 | |
| SCHEMBL28764573 | 0.70 | MEN1 (0.54) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009090548-A2 | 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-23 | — | — | WO | disclosed |