⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29635323 | 0.91 | AKT1 (0.33) | — | |
| SCHEMBL29635326 | 0.87 | HSD17B10 (0.34) | — | |
| SCHEMBL28888675 | 0.85 | MGLL (0.32) | — | |
| SCHEMBL28888674 | 0.85 | MGLL (0.32) | — | |
| SCHEMBL29825364 | 0.82 | AKT1 (0.35) | — | |
| SCHEMBL29825086 | 0.75 | OPRM1 (0.36) | — | |
| SCHEMBL20471019 | 0.75 | MGLL (0.33) | — | |
| SCHEMBL25153830 | 0.73 | — | — | |
| SCHEMBL16006043 | 0.73 | — | — | |
| SCHEMBL12892884 | 0.73 | PTGS1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250064964-A1 | ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION (GNF) | 2025-02-27 | — | — | US | disclosed |
| US-12180291-B2 | Anti-CCR7 antibody drug conjugates | NOVARTIS AG (CH) | 2024-12-31 | — | — | US | disclosed |
| US-12171839-B2 | Antibody drug conjugates for ablating hematopoietic stem cells | NOVARTIS AG (CH) | 2024-12-24 | — | — | US | disclosed |
| US-11634497-B2 | Anti-CCR7 antibody drug conjugates | NOVARTIS AG (CH) | 2023-04-25 | — | — | US | disclosed |
| EP-4142799-A1 | CCR7 ANTIBODY DRUG CONJUGATES FOR TREATING CANCER | Novartis AG (CH) | 2023-03-08 | — | — | EP | disclosed |
| US-20220305134-A1 | ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION (GNF) | 2022-09-29 | — | — | US | disclosed |
| US-11357864-B2 | Antibody drug conjugates for ablating hematopoietic stem cells | NOVARTIS AG (CH) | 2022-06-14 | — | — | US | disclosed |