Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CBFB | Q13951 | 11/20 | 0.52 |
| ▸ | METAP2 | P50579 | 7/20 | 0.52 |
| ▸ | METAP1 | P53582 | 5/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13203471 | 0.85 | ALDH1A1 (0.46) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2967910 | 0.84 | ALDH1A1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2978014 | 0.79 | KDM4E (0.65) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL13203478 | 0.79 | HDAC3 (0.43) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2978439 | 0.78 | CBFB (0.80) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2974133 | 0.78 | METAP2 (0.80) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL13203406 | 0.77 | NPC1 (0.76) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL16307579 | 0.70 | ALDH1A1 (0.53) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL12119033 | 0.69 | CBFB (1.00) | NPC1RAB9AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL13203469 | 0.69 | ALDH1A1 (0.67) | NPC1RAB9AKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777051-B2 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20050038067-A1 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2005-02-17 | — | — | US | disclosed |
| WO-2005002503-A2 | ASYMMETRIC BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038067-A1 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNJ1, KCNJ11 | NPC1 709/4885RAB9A 3606/4885KDM4E 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.