Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24410316 | 1.00 | CTNNB1 (0.45) | CTNNB1WNT3AMAPTALDH1A1KDM4E | |
| SCHEMBL20819374 | 0.79 | CTNNB1 (0.49) | CTNNB1WNT3AMAPTALDH1A1KDM4E | |
| SCHEMBL2380013 | 0.77 | CTNNB1 (0.48) | CTNNB1WNT3AMAPTALDH1A1KDM4E | |
| SCHEMBL9964038 | 0.77 | CTNNB1 (0.48) | CTNNB1WNT3AMAPTALDH1A1KDM4E | |
| SCHEMBL948485 | 0.77 | LMNA (0.56) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL31749123 | 0.76 | CTSA (0.42) | MAPTKDM4EMEN1KMT2APOLB | |
| SCHEMBL30131385 | 0.76 | EGLN1 (0.52) | ALDH1A1MEN1KMT2APOLBGRM4 | |
| Hydrochloric Acid SCHEMBL6110118 | 0.76 | CTNNB1 (0.47) | CTNNB1WNT3AMAPTALDH1A1KDM4E | |
| Bromide SCHEMBL6111604 | 0.76 | CTNNB1 (0.47) | CTNNB1WNT3AMAPTALDH1A1KDM4E | |
| SCHEMBL15988841 | 0.75 | CTNNB1 (0.56) | CTNNB1WNT3AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970485-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2024-04-30 | — | — | US | disclosed |
| US-20230265085-A1 | RET KINASE INHIBITORS | LOXO ONCOLOGY, INC. | 2023-08-24 | — | — | US | disclosed |
| US-11697647-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2023-07-11 | — | — | US | disclosed |
| US-20220144816-A1 | RET KINASE INHIBITORS | EVOTEC INTERNATIONAL GMBH (DE) | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11970485-B2 | RET kinase inhibitors | RET, BRAF, GFRA1 | CTNNB1 3442/4885WNT3A 2791/4885MAPT 2324/4885 |
| US-11697647-B2 | RET kinase inhibitors | RET, BRAF, GFRA1 | CTNNB1 3442/4885WNT3A 2791/4885MAPT 2324/4885 |
| US-20230265085-A1 | RET KINASE INHIBITORS | RET, BRAF, GFRA1 | CTNNB1 3442/4885WNT3A 2791/4885MAPT 2324/4885 |
| US-20220144816-A1 | RET KINASE INHIBITORS | RET, BRAF, GFRA1 | CTNNB1 3442/4885WNT3A 2791/4885MAPT 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.