SCHEMBL29633892

SCHEMBL29633892

COc1c(F)cc(CCC(C(=O)OC(C)(C)C)N(C)C(=O)OCC2c3ccccc3-c3ccccc32)cc1F

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FABP5 Q01469 2/20 0.34
EPHX2 P34913 1/20 0.34
MDM2 Q00987 2/20 0.32
KMT2A Q03164 1/20 0.31
FABP7 O15540 1/20 0.31
MDM4 O15151 1/20 0.30
TP53 P04637 1/20 0.30
ITGA4 P13612 1/20 0.30
ITGB7 P26010 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29633726 0.91 FABP5 (0.35) FABP5EPHX2MDM2KMT2AFABP7
SCHEMBL29633688 0.90 CHRM5 (0.38) FABP5
SCHEMBL29634078 0.89 FABP5 (0.38) FABP5EPHX2MDM2KMT2AFABP7
SCHEMBL29633663 0.86 PPIA (0.35) FABP5EPHX2MDM2KMT2AFABP7
SCHEMBL29633952 0.86 KMT2A (0.35) FABP5EPHX2MDM2KMT2AFABP7
SCHEMBL29633839 0.86 EPHX2 (0.33) FABP5EPHX2MDM2KMT2AFABP7
SCHEMBL29633761 0.86 FABP5 (0.38) FABP5EPHX2MDM2KMT2AFABP7
SCHEMBL29633852 0.86 FABP5 (0.39) FABP5KMT2A
SCHEMBL29633993 0.86 EPHX2 (0.37) EPHX2MDM2KMT2AMDM4TP53
SCHEMBL29633784 0.85 MDM2 (0.37) FABP5EPHX2MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240376044-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2024-11-14 US disclosed
US-12071396-B2 Method for preparing aromatic amino acid derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-08-27 US disclosed
US-20220144762-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240376044-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE DDC, AADAT, TYR FABP5 608/4885EPHX2 2165/4885MDM2 223/4885
US-20220144762-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE DDC, AADAT, TYR FABP5 608/4885EPHX2 2165/4885MDM2 223/4885
US-12071396-B2 Method for preparing aromatic amino acid derivative DDC, AADAT, TYR FABP5 608/4885EPHX2 2165/4885MDM2 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.