Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | MERTK | Q12866 | 3/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21174407 | 1.00 | BTK (0.46) | BTKROCK2AURKBAURKAMAPK1 | |
| SCHEMBL21174128 | 0.89 | MET (0.47) | BTKAURKBMAPK1MET | |
| SCHEMBL21174072 | 0.88 | USP30 (0.43) | ROCK2MAPK1MMP13WDR5 | |
| SCHEMBL21174206 | 0.87 | EGLN2 (0.39) | BTKAURKBMET | |
| SCHEMBL21174180 | 0.86 | KDM1A (0.44) | MMP13 | |
| SCHEMBL21174056 | 0.83 | MET (0.43) | BTKMET | |
| SCHEMBL21174395 | 0.82 | POLB (0.42) | MAPK1 | |
| SCHEMBL21174373 | 0.81 | ROCK2 (0.43) | ROCK2MMP13 | |
| SCHEMBL21174140 | 0.81 | CCKBR (0.42) | ROCK2MAPK1 | |
| SCHEMBL21174367 | 0.81 | MET (0.44) | BTKAURKBMAPK1CLK1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3514149-B1 | HETEROCYCLIC AMIDE COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2022-05-18 | — | — | EP | disclosed |