Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634706 | 0.92 | GRM5 (0.45) | GRM5ALKBH1CYP11B2 | |
| SCHEMBL24409029 | 0.82 | GPR119 (0.43) | GRM5CYP11B2 | |
| SCHEMBL21834134 | 0.70 | GABRG2 (0.47) | GRM5FFAR1 | |
| SCHEMBL29634722 | 0.67 | TRPM8 (0.32) | — | |
| SCHEMBL29634705 | 0.66 | TRPM8 (0.34) | — | |
| SCHEMBL2891543 | 0.65 | GRM5 (0.56) | GRM5 | |
| SCHEMBL3108697 | 0.65 | HRH4 (0.46) | GRM5 | |
| SCHEMBL29634703 | 0.64 | TRPM8 (0.34) | — | |
| SCHEMBL4129398 | 0.64 | KCNH2 (0.45) | GRM5 | |
| SCHEMBL10313037 | 0.63 | PTGS1 (0.47) | GRM5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |