Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | CALCR | P30988 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 4/20 | 0.43 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30512636 | 0.87 | CALCRL (0.56) | MAPK8MAPK9MAPK10CALCRLREN | |
| SCHEMBL29506917 | 0.86 | CXCL8 (0.52) | CALCRF2APLNR | |
| SCHEMBL29506916 | 0.86 | APLNR (0.52) | MAPK8MAPK9MAPK10CALCRLHCRTR1 | |
| SCHEMBL29634976 | 0.85 | MAPK8 (0.54) | MAPK8MAPK9MAPK10CALCRLREN | |
| SCHEMBL29614861 | 0.83 | CALCRL (0.46) | MAPK8MAPK9MAPK10CALCRLHCRTR1 | |
| SCHEMBL29634931 | 0.80 | CALCRL (0.53) | MAPK8MAPK9MAPK10CALCRLREN | |
| SCHEMBL30974474 | 0.80 | CALCRL (0.59) | CALCRLRENCALCRF2RAMP1 | |
| SCHEMBL29630400 | 0.80 | REN (0.44) | REN | |
| SCHEMBL29630379 | 0.79 | REN (0.39) | RENF2 | |
| SCHEMBL29591797 | 0.78 | REN (0.43) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4274835-A1 | COMPOUNDS COMPRISING A FIBROBLAST ACTIVATION PROTEIN LIGAND AND USE THEREOF | 3B Pharmaceuticals GmbH (DE) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022148843-A1 | COMPOUNDS COMPRISING A FIBROBLAST ACTIVATION PROTEIN LIGAND AND USE THEREOF | 3B PHARMACEUTICALS GMBH (DE) | 2022-07-14 | — | — | WO | disclosed |
| EP-3997104-A1 | COMPOUNDS COMPRISING A FIBROBLAST ACTIVATION PROTEIN LIGAND AND USE THEREOF | 3B Pharmaceuticals GmbH (DE) | 2022-05-18 | — | — | EP | disclosed |