Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10995189 | 1.00 | KDM4E (0.49) | KDM4ELMNAPKMSMN1; SMN2GAA | |
| SCHEMBL3637105 | 0.91 | KDM4E (0.53) | KDM4ELMNAPKMSMN1; SMN2GAA | |
| SCHEMBL12575834 | 0.86 | LMNA (0.51) | KDM4ELMNAPKMSMN1; SMN2GAA | |
| SCHEMBL12490739 | 0.83 | KDM4E (0.47) | KDM4ELMNAPKMSMN1; SMN2GAA | |
| SCHEMBL31368630 | 0.81 | KMT2A (0.41) | KDM4ELMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL62649 | 0.81 | KMT2A (0.41) | KDM4ELMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL31368629 | 0.81 | KMT2A (0.41) | KDM4ELMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL24747246 | 0.80 | LMNA (0.44) | KDM4ELMNAPKMSMN1; SMN2GAA | |
| SCHEMBL14725188 | 0.80 | ALDH1A1 (0.46) | KDM4ELMNAPKMSMN1; SMN2GAA | |
| SCHEMBL24683837 | 0.80 | KDM4E (0.55) | KDM4ELMNAPKMSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |