Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015138 | 1.00 | DHODH (0.45) | DHODHCYP2D6CYP2C19MAPK1CYP1A2 | |
| SCHEMBL28967174 | 0.84 | KMT2A (0.42) | CYP2D6CYP2C19MAPK1CYP1A2MEN1 | |
| SCHEMBL29636644 | 0.84 | KMT2A (0.42) | CYP2D6CYP2C19MAPK1CYP1A2MEN1 | |
| SCHEMBL23015145 | 0.81 | ALDH1A1 (0.47) | DHODHMAPK1MAPTALDH1A1HPGD | |
| SCHEMBL29874965 | 0.81 | ALDH1A1 (0.47) | DHODHMAPK1MAPTALDH1A1HPGD | |
| SCHEMBL23015213 | 0.79 | MET (0.48) | CYP2C19CYP1A2 | |
| SCHEMBL29636634 | 0.79 | MET (0.48) | CYP2C19CYP1A2 | |
| SCHEMBL10730742 | 0.79 | ACP1 (0.45) | CYP2D6CYP2C19MAPK1CYP1A2MEN1 | |
| SCHEMBL23029691 | 0.77 | ACP1 (0.58) | ACP1 | |
| SCHEMBL28967193 | 0.75 | ALDH1A1 (0.59) | CYP2D6CYP2C19MAPK1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |