Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28967174 | 1.00 | KMT2A (0.42) | KMT2AMEN1POLBHRH4ALDH1A1 | |
| SCHEMBL23015138 | 0.84 | DHODH (0.45) | KMT2AMEN1ALDH1A1HPGDSLC18A3 | |
| SCHEMBL29636642 | 0.84 | DHODH (0.45) | KMT2AMEN1ALDH1A1HPGDSLC18A3 | |
| SCHEMBL30998387 | 0.76 | HRH4 (0.50) | KMT2AMEN1POLBHRH4ALDH1A1 | |
| SCHEMBL23015213 | 0.76 | MET (0.48) | CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL29636634 | 0.76 | MET (0.48) | CYP1A2CYP2C19CYP3A4 | |
| Hydrochloric Acid SCHEMBL29862942 | 0.75 | KMT2A (0.49) | KMT2AMEN1POLBHRH4ALDH1A1 | |
| SCHEMBL23015130 | 0.74 | ACP1 (0.49) | ACP1 | |
| SCHEMBL29636724 | 0.74 | ACP1 (0.49) | ACP1 | |
| SCHEMBL23015298 | 0.73 | SIGMAR1 (0.40) | ALDH1A1HTTSIGMAR1MAOBHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |