Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28967176 | 1.00 | KDM4E (0.51) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL28967193 | 0.84 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTLMNAHPGD | |
| Hydrochloric Acid SCHEMBL29636779 | 0.83 | ALDH1A1 (0.57) | KDM4EALDH1A1MAPTLMNAHPGD | |
| SCHEMBL23015241 | 0.81 | KDM4E (0.46) | KDM4ESLC2A1ALDH1A1MAPTHPGD | |
| SCHEMBL29636719 | 0.77 | ALDH1A1 (0.49) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL29875058 | 0.74 | PLA2G2A (0.50) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL23029741 | 0.74 | SYK (0.62) | SYKACP1 | |
| SCHEMBL29874547 | 0.74 | SYK (0.62) | SYKACP1 | |
| SCHEMBL23015316 | 0.74 | KDM4E (0.61) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29636817 | 0.74 | KDM4E (0.61) | KDM4EMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |
| WO-2024054807-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |