Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ACACA | Q13085 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28967193 | 0.92 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4ELMNAACACA | |
| Hydrochloric Acid SCHEMBL29636779 | 0.91 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ELMNAACACA | |
| SCHEMBL28967176 | 0.77 | KDM4E (0.51) | ALDH1A1HPGDKDM4ELMNAACACA | |
| SCHEMBL29636666 | 0.77 | KDM4E (0.51) | ALDH1A1HPGDKDM4ELMNAACACA | |
| SCHEMBL23015208 | 0.76 | ACP1 (0.63) | ACP1SYK | |
| SCHEMBL20414389 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4ELMNAACACA | |
| SCHEMBL29636726 | 0.74 | GRM2 (0.46) | ALDH1A1KDM4ELMNAMAPTMAPK1 | |
| SCHEMBL29636711 | 0.74 | NPC1 (0.46) | NPC1RAB9ASYK | |
| SCHEMBL23015344 | 0.74 | GRM2 (0.46) | ALDH1A1KDM4ELMNAMAPTMAPK1 | |
| SCHEMBL23015380 | 0.73 | ACP1 (0.65) | ALDH1A1HPGDKDM4ELMNAACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |