Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | TP53 | P04637 | 4/20 | 0.74 |
| ▸ | GAA | P10253 | 3/20 | 0.74 |
| ▸ | MMP2 | P08253 | 1/20 | 0.71 |
| ▸ | MMP9 | P14780 | 1/20 | 0.71 |
| ▸ | MMP8 | P22894 | 1/20 | 0.71 |
| ▸ | MMP13 | P45452 | 1/20 | 0.71 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | MGLL | Q99685 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105704 | 1.00 | RAB9A (0.74) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL20379246 | 0.87 | MMP2 (0.78) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL10709034 | 0.87 | MGLL (0.70) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL31000016 | 0.85 | MMP2 (0.67) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL2247443 | 0.85 | SMN1; SMN2 (1.00) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL2245559 | 0.85 | TP53 (0.69) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL2248424 | 0.85 | RAB9A (0.78) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL27451199 | 0.84 | RAB9A (0.67) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL31000021 | 0.83 | MAPT (0.69) | RAB9AKDM4ENPC1SMN1; SMN2TP53 | |
| SCHEMBL1987139 | 0.83 | MMP2 (1.00) | RAB9AKDM4ENPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017873-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL PAIN AND ITCH | Duke University (US) | 2022-06-29 | — | — | EP | claimed |