Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30998387 | 0.87 | HRH4 (0.50) | NCF1POLBACHEKMT2AHPGD | |
| Hydrochloric Acid SCHEMBL29862942 | 0.86 | KMT2A (0.49) | NCF1POLBACHEKMT2AHPGD | |
| SCHEMBL29636637 | 0.85 | HTR3A (0.51) | NCF1POLBACHEKMT2AHPGD | |
| SCHEMBL29636762 | 0.82 | NCF1 (0.38) | NCF1POLBACHEKMT2AHPGD | |
| SCHEMBL31677954 | 0.73 | POLB (0.49) | NCF1POLBACHEHPGDSMN1; SMN2 | |
| SCHEMBL24288997 | 0.71 | KMT2A (0.42) | KMT2AHPGDSMN1; SMN2BMPR1BBMPR1A | |
| Hydrochloric Acid SCHEMBL29862880 | 0.70 | KMT2A (0.46) | POLBACHEKMT2AHPGDHTR3A | |
| SCHEMBL25361079 | 0.69 | PARP1 (0.61) | KHKPARP1 | |
| SCHEMBL27866891 | 0.68 | NCF1 (0.69) | NCF1ACHEKMT2AHPGDHTR3A | |
| Hydrochloric Acid SCHEMBL28834209 | 0.67 | HRH4 (0.46) | KMT2AMEN1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | disclosed |