Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557281 | 1.00 | KMT2A (0.39) | KMT2AMAPK1USP2TSHRSMN1; SMN2 | |
| SCHEMBL29638384 | 0.89 | AKR1C3 (0.39) | HPGDPOLBAKR1C3TYK2JAK1 | |
| SCHEMBL29638437 | 0.85 | HPGD (0.40) | KMT2ASMN1; SMN2KDM4EMEN1HPGD | |
| SCHEMBL29638464 | 0.85 | NPC1 (0.41) | KMT2ATSHRMEN1HPGDMAPT | |
| SCHEMBL24557258 | 0.85 | NPC1 (0.41) | KMT2ATSHRMEN1HPGDMAPT | |
| SCHEMBL29638414 | 0.84 | TYK2 (0.35) | HPGDMAPTPOLBAKR1C3TYK2 | |
| SCHEMBL29638472 | 0.84 | POLB (0.39) | MAPK1MAPTPOLBTYK2L3MBTL1 | |
| SCHEMBL24557251 | 0.82 | JAK2 (0.37) | HPGDMAPTTYK2JAK1 | |
| SCHEMBL24557266 | 0.82 | JAK1 (0.41) | HPGDTYK2JAK1 | |
| SCHEMBL29638316 | 0.82 | JAK1 (0.41) | HPGDTYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |