Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.32 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638325 | 0.90 | TP53 (0.39) | AKR1C3NNMTTYK2JAK1TP53 | |
| SCHEMBL29638342 | 0.89 | KMT2A (0.39) | AKR1C3TYK2JAK1TP53POLB | |
| SCHEMBL24557281 | 0.89 | KMT2A (0.39) | AKR1C3TYK2JAK1TP53POLB | |
| SCHEMBL29638437 | 0.86 | HPGD (0.40) | TYK2TP53GAAALDH1A1HPGD | |
| SCHEMBL29638464 | 0.86 | NPC1 (0.41) | AKR1C3TYK2TP53POLBGAA | |
| SCHEMBL24557258 | 0.86 | NPC1 (0.41) | AKR1C3TYK2TP53POLBGAA | |
| SCHEMBL29638414 | 0.85 | TYK2 (0.35) | AKR1C3TYK2JAK1POLBGAA | |
| SCHEMBL24557251 | 0.83 | JAK2 (0.37) | TYK2JAK1MAP3K12HPGDJAK2 | |
| SCHEMBL29638468 | 0.83 | TRPV1 (0.39) | TYK2SYKMAP3K12GAACDK4 | |
| SCHEMBL29638415 | 0.83 | JAK2 (0.37) | TYK2JAK1MAP3K12HPGDJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |