Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PMM2 | O15305 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638512 | 0.90 | PLK1 (0.42) | TYK2PLK1 | |
| SCHEMBL24557357 | 0.90 | PLK1 (0.42) | TYK2PLK1 | |
| SCHEMBL24557361 | 0.84 | MAPT (0.45) | TYK2RAB9AMAPTNPC1LMNA | |
| SCHEMBL29638464 | 0.84 | NPC1 (0.41) | TYK2ALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL24557258 | 0.84 | NPC1 (0.41) | TYK2ALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL24557263 | 0.83 | TYK2 (0.39) | TYK2JAK1ALDH1A1KDM4EMAPT | |
| SCHEMBL29638451 | 0.83 | TYK2 (0.39) | TYK2JAK1ALDH1A1KDM4EMAPT | |
| SCHEMBL29638528 | 0.83 | TYK2 (0.33) | TYK2JAK1MAPTMEN1KMT2A | |
| SCHEMBL24557308 | 0.82 | TYK2 (0.40) | TYK2JAK1ALDH1A1MAPTLMNA | |
| SCHEMBL29638404 | 0.82 | TYK2 (0.40) | TYK2JAK1ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |