Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 3/20 | 0.32 |
| ▸ | LYN | P07948 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638352 | 0.89 | ABCG2 (0.37) | TYK2TP53BTKLYNSRC | |
| SCHEMBL29638438 | 0.87 | TYK2 (0.36) | TYK2TP53JAK1MAPT | |
| SCHEMBL24557361 | 0.85 | MAPT (0.45) | TYK2LYNSRCPOLBGAA | |
| SCHEMBL29638464 | 0.84 | NPC1 (0.41) | TYK2TP53BTKLYNSRC | |
| SCHEMBL24557258 | 0.84 | NPC1 (0.41) | TYK2TP53BTKLYNSRC | |
| SCHEMBL24557263 | 0.84 | TYK2 (0.39) | TYK2BTKSRCJAK1POLB | |
| SCHEMBL29638451 | 0.84 | TYK2 (0.39) | TYK2BTKSRCJAK1POLB | |
| SCHEMBL24557308 | 0.83 | TYK2 (0.40) | TYK2TP53JAK1MAPTMEN1 | |
| SCHEMBL29638404 | 0.83 | TYK2 (0.40) | TYK2TP53JAK1MAPTMEN1 | |
| SCHEMBL29638367 | 0.83 | TYK2 (0.36) | TYK2JAK1GAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |