Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 6/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638475 | 0.92 | AXL (0.39) | MAP4K1TYK2AXLTYRO3MERTK | |
| SCHEMBL29638404 | 0.86 | TYK2 (0.40) | TYK2JAK1 | |
| SCHEMBL24557308 | 0.86 | TYK2 (0.40) | TYK2JAK1 | |
| SCHEMBL29638482 | 0.83 | TYK2 (0.35) | TYK2JAK1 | |
| SCHEMBL29638310 | 0.82 | ALDH1A1 (0.40) | TYK2JAK1 | |
| SCHEMBL24557356 | 0.82 | PHGDH (0.36) | TYK2JAK1MAPK1 | |
| SCHEMBL29638350 | 0.82 | PHGDH (0.36) | TYK2JAK1MAPK1 | |
| SCHEMBL24557361 | 0.82 | MAPT (0.45) | TYK2 | |
| SCHEMBL29638312 | 0.82 | IGF1R (0.41) | TYK2MAPK1 | |
| SCHEMBL24557258 | 0.81 | NPC1 (0.41) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |