Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 7/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | GALR2 | O43603 | 1/20 | 0.32 |
| ▸ | GALR1 | P47211 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638482 | 0.92 | TYK2 (0.35) | ALDH1A1POLBPKMTYK2JAK1 | |
| SCHEMBL29638345 | 0.91 | GABRA1 (0.39) | ALDH1A1POLBPKMTYK2PIK3CA | |
| SCHEMBL24557356 | 0.89 | PHGDH (0.36) | TYK2PIK3CAPRKDCJAK1TP53 | |
| SCHEMBL29638350 | 0.89 | PHGDH (0.36) | TYK2PIK3CAPRKDCJAK1TP53 | |
| SCHEMBL29638404 | 0.89 | TYK2 (0.40) | ALDH1A1TYK2PIK3CAPRKDCJAK1 | |
| SCHEMBL24557308 | 0.89 | TYK2 (0.40) | ALDH1A1TYK2PIK3CAPRKDCJAK1 | |
| SCHEMBL24557263 | 0.86 | TYK2 (0.39) | ALDH1A1POLBPKMTYK2JAK1 | |
| SCHEMBL29638451 | 0.86 | TYK2 (0.39) | ALDH1A1POLBPKMTYK2JAK1 | |
| SCHEMBL24557361 | 0.85 | MAPT (0.45) | POLBTYK2PRKDCMAPTPLK1 | |
| SCHEMBL29638475 | 0.85 | AXL (0.39) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |