SCHEMBL29638482 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	TYK2	P29597	6/20	0.35

▸	JAK1	P23458	1/20	0.35

▸	TP53	P04637	1/20	0.34

▸	PLK1	P53350	1/20	0.34

▸	ALDH1A1	P00352	1/20	0.34

▸	POLB	P06746	1/20	0.34

▸	PKM	P14618	1/20	0.34

▸	RET	P07949	1/20	0.33

▸	MAPT	P10636	1/20	0.33

▸	SYK	P43405	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29638310	0.92	ALDH1A1 (0.40)	TYK2JAK1TP53PLK1ALDH1A1
SCHEMBL24557308	0.90	TYK2 (0.40)	TYK2JAK1TP53PLK1ALDH1A1
SCHEMBL29638404	0.90	TYK2 (0.40)	TYK2JAK1TP53PLK1ALDH1A1
SCHEMBL29638350	0.86	PHGDH (0.36)	TYK2JAK1TP53PLK1
SCHEMBL24557356	0.86	PHGDH (0.36)	TYK2JAK1TP53PLK1
SCHEMBL24557361	0.85	MAPT (0.45)	TYK2PLK1POLBMAPT
SCHEMBL29638475	0.85	AXL (0.39)	TYK2
SCHEMBL24557258	0.85	NPC1 (0.41)	TYK2TP53ALDH1A1POLBMAPT
SCHEMBL29638464	0.85	NPC1 (0.41)	TYK2TP53ALDH1A1POLBMAPT
SCHEMBL24557263	0.85	TYK2 (0.39)	TYK2JAK1PLK1ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022136914-A1	TYK2 INHIBITORS AND USES THEREOF	SUDO BIOSCIENCES LIMITED (GB)	2022-06-30	—	—	WO	disclosed