Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638325 | 0.93 | TP53 (0.39) | AKR1C3TP53TYK2JAK1POLB | |
| SCHEMBL24557258 | 0.88 | NPC1 (0.41) | AKR1C3TP53TYK2POLBGAA | |
| SCHEMBL29638464 | 0.88 | NPC1 (0.41) | AKR1C3TP53TYK2POLBGAA | |
| SCHEMBL24557361 | 0.86 | MAPT (0.45) | TYK2POLBGAAMEN1KMT2A | |
| SCHEMBL29638451 | 0.85 | TYK2 (0.39) | TYK2JAK1POLBGAAKDM4E | |
| SCHEMBL24557263 | 0.85 | TYK2 (0.39) | TYK2JAK1POLBGAAKDM4E | |
| SCHEMBL29638388 | 0.85 | NOX4 (0.41) | TP53TYK2JAK1GAAMEN1 | |
| SCHEMBL29638352 | 0.85 | ABCG2 (0.37) | AKR1C3TP53TYK2JAK1POLB | |
| SCHEMBL24557308 | 0.85 | TYK2 (0.40) | TP53TYK2JAK1MEN1KMT2A | |
| SCHEMBL29638404 | 0.85 | TYK2 (0.40) | TP53TYK2JAK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |