Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 5/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638398 | 0.89 | CDK4 (0.40) | SYKTYK2KDM4EGAAMAPT | |
| SCHEMBL29638466 | 0.88 | MAPT (0.39) | TYK2MAPT | |
| SCHEMBL24557273 | 0.88 | MAPT (0.39) | TYK2MAPT | |
| SCHEMBL29638414 | 0.88 | TYK2 (0.35) | TYK2GAAMAPT | |
| SCHEMBL29638472 | 0.87 | POLB (0.39) | TYK2MAPT | |
| SCHEMBL29638437 | 0.87 | HPGD (0.40) | TYK2KDM4EGAAMAPTSMN1; SMN2 | |
| SCHEMBL29638464 | 0.86 | NPC1 (0.41) | TYK2GAAMAPT | |
| SCHEMBL24557258 | 0.86 | NPC1 (0.41) | TYK2GAAMAPT | |
| SCHEMBL24557251 | 0.84 | JAK2 (0.37) | MAP3K12TYK2MAPT | |
| SCHEMBL29638473 | 0.84 | TYK2 (0.40) | TYK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |