Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 9/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30559436 | 0.81 | BRAF (0.43) | SYKCCNCCDK8 | |
| SCHEMBL24399682 | 0.81 | BRAF (0.43) | SYKCCNCCDK8 | |
| SCHEMBL25374256 | 0.77 | BRAF (0.39) | SYKCCNCCDK8HDAC3HDAC1 | |
| SCHEMBL29638686 | 0.75 | EGFR (0.52) | SYKPOLB | |
| SCHEMBL13960088 | 0.74 | SLC6A4 (0.46) | — | |
| SCHEMBL23624389 | 0.72 | ABL1 (0.49) | TNF | |
| SCHEMBL13686770 | 0.70 | MAPK1 (0.56) | POLBTNF | |
| SCHEMBL29638477 | 0.69 | TNF (0.57) | TNF | |
| SCHEMBL29638533 | 0.69 | NCOA1 (0.60) | TNF | |
| SCHEMBL374483 | 0.69 | CDK5 (0.46) | SYKCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |