Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | FGR | P09769 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557290 | 1.00 | TYK2 (0.37) | TYK2GAAL3MBTL1MEN1ALDH1A1 | |
| SCHEMBL29638437 | 0.90 | HPGD (0.40) | TYK2GAAMEN1ALDH1A1KMT2A | |
| SCHEMBL29638376 | 0.89 | TYK2 (0.40) | TYK2ALDH1A1MAPK13ABL1EGFR | |
| SCHEMBL27199230 | 0.89 | TYK2 (0.40) | TYK2ALDH1A1MAPK13ABL1EGFR | |
| SCHEMBL24557293 | 0.89 | CYP11B2 (0.37) | TYK2CYP11B2 | |
| SCHEMBL29638460 | 0.89 | CYP11B2 (0.37) | TYK2CYP11B2 | |
| SCHEMBL24557361 | 0.88 | MAPT (0.45) | TYK2GAAMEN1KMT2AMAPK13 | |
| SCHEMBL24557298 | 0.87 | TYK2 (0.38) | TYK2GAAMEN1KMT2AMAPK13 | |
| SCHEMBL29638344 | 0.87 | TYK2 (0.38) | TYK2GAAMEN1KMT2AMAPK13 | |
| SCHEMBL24557258 | 0.85 | NPC1 (0.41) | TYK2GAAL3MBTL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |