Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.40 |
| ▸ | BRD4 | O60885 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | YES1 | P07947 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27199230 | 1.00 | TYK2 (0.40) | TYK2BRD4JAK1PKMTP53 | |
| SCHEMBL24557290 | 0.89 | TYK2 (0.37) | TYK2POLBNOTUMALDH1A1MAPK13 | |
| SCHEMBL29638542 | 0.89 | TYK2 (0.37) | TYK2POLBNOTUMALDH1A1MAPK13 | |
| SCHEMBL29638416 | 0.89 | TYK2 (0.40) | TYK2JAK1ALDH1A1 | |
| SCHEMBL24557269 | 0.89 | TYK2 (0.40) | TYK2JAK1ALDH1A1 | |
| SCHEMBL29638340 | 0.88 | TYK2 (0.36) | TYK2JAK1 | |
| SCHEMBL29638471 | 0.86 | IDH1 (0.34) | TYK2JAK1ALDH1A1 | |
| SCHEMBL29638437 | 0.85 | HPGD (0.40) | TYK2TP53MAPTALDH1A1 | |
| SCHEMBL29638329 | 0.84 | FGFR4 (0.36) | TYK2POLBMAPTALDH1A1 | |
| SCHEMBL24557308 | 0.84 | TYK2 (0.40) | TYK2JAK1TP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |