Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | OGT | O15294 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741924 | 1.00 | HSD17B1 (0.53) | HSD17B1HSD17B2KEAP1NFE2L2PTGS2 | |
| SCHEMBL30190454 | 0.80 | HSD17B1 (0.71) | HSD17B1HSD17B2FLT3GSK3BMAPT | |
| SCHEMBL23557823 | 0.80 | HSD17B1 (0.71) | HSD17B1HSD17B2FLT3GSK3BMAPT | |
| SCHEMBL1119554 | 0.77 | PTGS2 (0.66) | HSD17B1HSD17B2KEAP1NFE2L2PTGS2 | |
| SCHEMBL22944687 | 0.76 | CBLB (0.53) | — | |
| SCHEMBL28940698 | 0.76 | KEAP1 (0.59) | HSD17B1HSD17B2KEAP1NFE2L2PTGS2 | |
| SCHEMBL29626830 | 0.76 | KEAP1 (0.59) | HSD17B1HSD17B2KEAP1NFE2L2PTGS2 | |
| Bromide SCHEMBL6256547 | 0.76 | PTGS2 (0.64) | HSD17B1HSD17B2KEAP1NFE2L2PTGS2 | |
| SCHEMBL12420297 | 0.76 | PTGS2 (0.61) | HSD17B1HSD17B2PTGS2FLT3GSK3B | |
| SCHEMBL29350034 | 0.76 | KEAP1 (0.66) | HSD17B1HSD17B2KEAP1NFE2L2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |