Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76982 | 0.68 | ELANE (0.53) | TSHRGAAALDH1A1F2PLG | |
| SCHEMBL918512 | 0.68 | NR3C2 (0.56) | TSHRALDH1A1CYP2C19HTT | |
| Bromide SCHEMBL4613403 | 0.66 | NR3C2 (0.55) | TSHRALDH1A1CYP2C19HTT | |
| SCHEMBL9446230 | 0.66 | NR3C2 (0.59) | TSHRALDH1A1CYP2C19HTTMEN1 | |
| SCHEMBL29899841 | 0.66 | GABRA1 (0.41) | TSHRALDH1A1HPGDCYP1A2HTT | |
| SCHEMBL14198324 | 0.66 | NR3C2 (0.39) | TSHRALDH1A1CYP1A2KMT2A | |
| SCHEMBL290791 | 0.65 | POLB (0.70) | ALDH1A1F2PLGELANECTSG | |
| SCHEMBL27562818 | 0.65 | NPSR1 (0.78) | GAAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| Ethylene SCHEMBL11428459 | 0.64 | NR3C2 (0.53) | TSHRGAAALDH1A1CYP2C19HTT | |
| SCHEMBL11620172 | 0.64 | ELANE (0.57) | GAAALDH1A1F2PLGELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502161-B | Use of heterocyclic derivatives with cardiomyocyte proliferative activity in the treatment of heart diseases | 上海市东方医院（同济大学附属东方医院） | 2024-03-29 | — | — | CN | disclosed |
| CN-114929690-B | Novel heterocyclic derivatives having cardiomyocyte proliferative activity for the treatment of heart disease | 同济大学 | 2023-05-05 | — | — | CN | disclosed |
| CN-114929690-A | Novel heterocyclic derivatives with cardiomyocyte proliferative activity for the treatment of cardiac diseases | 同济大学 | 2022-08-19 | — | — | CN | disclosed |
| CN-114502161-A | Use of heterocyclic derivatives having cardiomyocyte proliferative activity for the treatment of cardiac diseases | 上海市东方医院（同济大学附属东方医院） | 2022-05-13 | — | — | CN | disclosed |