Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918512 | 0.97 | NR3C2 (0.56) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL9446230 | 0.95 | NR3C2 (0.59) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| Ethylene SCHEMBL11428459 | 0.92 | NR3C2 (0.53) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL9215401 | 0.92 | HDAC1 (0.60) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL1702260 | 0.88 | NR3C2 (0.54) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL9215743 | 0.85 | TAAR1 (0.56) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL9446253 | 0.84 | NR3C2 (0.51) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL5841663 | 0.84 | MAPT (0.56) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL18590698 | 0.84 | KCNA3 (0.49) | NR3C2HDAC1HDAC8HDAC6TSHR | |
| SCHEMBL9446233 | 0.84 | NR3C2 (0.51) | NR3C2HDAC1HDAC8HDAC6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453896-B1 | PROCESS FOR MODIFYING A POLYMERIC SURFACE | 3M INNOVATIVE PROPERTIES CO (US) | 2008-04-09 | — | — | EP | disclosed |