Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
| ▸ | NEK4 | P51957 | 1/20 | 0.34 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29627860 | 1.00 | ROCK2 (0.38) | ROCK2ROCK1CHEK2PRKACARPS6KA3 | |
| SCHEMBL25195353 | 1.00 | ROCK2 (0.38) | ROCK2ROCK1CHEK2PRKACARPS6KA3 | |
| SCHEMBL25207952 | 0.86 | FFAR1 (0.42) | FFAR1TAOK1CLK4SLC22A12NPC1 | |
| SCHEMBL30356666 | 0.85 | FFAR1 (0.32) | FFAR1EGFRITKAAK1 | |
| SCHEMBL25196396 | 0.85 | FFAR1 (0.32) | FFAR1EGFRITKAAK1 | |
| SCHEMBL25208361 | 0.85 | AAK1 (0.36) | FFAR1AAK1GABRA1GABRG2GABRB3 | |
| SCHEMBL30356700 | 0.85 | AAK1 (0.36) | FFAR1AAK1GABRA1GABRG2GABRB3 | |
| SCHEMBL29627907 | 0.85 | FFAR1 (0.36) | FFAR1SLC22A12HSP90AB1HAO1 | |
| SCHEMBL25192876 | 0.84 | FFAR1 (0.35) | FFAR1AAK1GABRA1GABRG2GABRB3 | |
| SCHEMBL30356727 | 0.84 | FFAR1 (0.35) | FFAR1AAK1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209658-A | Inhibitors of RHO-associated coiled coil kinase | 安吉昂生物医药公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-114502163-A | Ethynylheterocycles as RHO-related coiled coil kinase (ROCK) inhibitors | 安吉昂生物医药公司 | 2022-05-13 | — | — | CN | disclosed |