Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28531300 | 1.00 | AURKA (0.45) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL23682527 | 1.00 | AURKA (0.45) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL28524920 | 0.90 | AURKA (0.44) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL29643010 | 0.90 | AURKA (0.44) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL21598776 | 0.84 | NOS3 (0.43) | AURKASIRT2PTPRBNOS3NOS1 | |
| SCHEMBL21598775 | 0.84 | NOS3 (0.43) | AURKASIRT2PTPRBNOS3NOS1 | |
| SCHEMBL29642978 | 0.83 | METAP1 (0.40) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL28531299 | 0.78 | CTSA (0.39) | PTPRB | |
| SCHEMBL2367233 | 0.77 | SLC7A5 (0.64) | AURKARPS6KB1CYP17A1SLC7A5NOS3 | |
| SCHEMBL16856591 | 0.77 | AURKA (0.47) | AURKARPS6KB1SIRT2CYP17A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240352122-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | NOVARTIS AG (CH) | 2024-10-24 | — | — | US | disclosed |
| US-11999786-B2 | Anti-CD48 antibodies, antibody drug conjugates, and uses thereof | NOVARTIS AG (CH) | 2024-06-04 | — | — | US | disclosed |
| EP-4251648-A2 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | Novartis AG (CH) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022112942-A2 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | NOVARTIS AG (CH) | 2022-06-02 | — | — | WO | disclosed |
| US-20220162308-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | NOVARTIS AG (CH) | 2022-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999786-B2 | Anti-CD48 antibodies, antibody drug conjugates, and uses thereof | ITGB8, ITGA8, CD4 | AURKA 1956/4885RPS6KB1 3097/4885SIRT2 4455/4885 |
| US-20240352122-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | ITGB8, ITGA8, CD4 | AURKA 1956/4885RPS6KB1 3097/4885SIRT2 4455/4885 |
| US-20220162308-A1 | ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF | ITGB8, ITGA8, CD4 | AURKA 1956/4885RPS6KB1 3097/4885SIRT2 4455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.