Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29643010 | 1.00 | AURKA (0.44) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL29642984 | 0.90 | AURKA (0.45) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL28531300 | 0.90 | AURKA (0.45) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL23682527 | 0.90 | AURKA (0.45) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL29642978 | 0.85 | METAP1 (0.40) | AURKARPS6KB1SIRT2METAP1CYP17A1 | |
| SCHEMBL21598768 | 0.83 | MAPT (0.43) | AURKA | |
| SCHEMBL21598770 | 0.83 | MAPT (0.43) | AURKA | |
| SCHEMBL28524919 | 0.77 | CTSA (0.40) | — | |
| SCHEMBL27554182 | 0.77 | SLC7A5 (0.46) | AURKARPS6KB1SIRT2CYP17A1HDAC3 | |
| SCHEMBL7609410 | 0.75 | L3MBTL1 (0.44) | METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112437675-A | Antibody drug conjugates for ablating hematopoietic stem cells | 诺华股份有限公司 | 2021-03-02 | — | — | CN | disclosed |