Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975479 | 1.00 | MAOB (0.50) | MAOBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3974252 | 0.98 | MEN1 (0.50) | MAOBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2979758 | 0.85 | MC4R (0.53) | MEN1KMT2AALDH1A1KDM4EHRH4 | |
| SCHEMBL28842755 | 0.81 | CYP2A13 (0.49) | MEN1KMT2AALDH1A1KDM4EHRH3 | |
| SCHEMBL2995258 | 0.81 | MEN1 (0.41) | MAOBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL15471355 | 0.81 | MEN1 (0.44) | MAOBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14375356 | 0.80 | ACHE (0.54) | MEN1KMT2AALDH1A1KDM4EHRH3 | |
| SCHEMBL13003775 | 0.79 | MEN1 (0.48) | MEN1KMT2AALDH1A1KDM4ECYP2D6 | |
| SCHEMBL16026534 | 0.79 | MEN1 (0.48) | MAOBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17968032 | 0.79 | PARP1 (0.47) | MEN1KMT2AALDH1A1KDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776903-B2 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| EP-1753757-B1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2008-12-10 | — | — | EP | disclosed |
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
| EP-1753757-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2007-02-21 | — | — | EP | disclosed |
| EP-1578416-B1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2006-08-02 | — | — | EP | disclosed |
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
| WO-2005113549-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |
| EP-1578416-A1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058248-A1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | THPO, ADCYAP1R1, DPYD | MAOB 497/4885MEN1 1349/4885KMT2A 2739/4885 |
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | OPRL1, OPRK1, OPRM1 | MAOB 56/4885MEN1 4716/4885KMT2A 3805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.