Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 7/20 | 1.00 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22619593 | 1.00 | TRPC5 (1.00) | TRPC5TRPC4SMN1; SMN2HTTUSP2 | |
| SCHEMBL1170660 | 0.85 | ALDH1A1 (0.86) | TRPC5TRPC4SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL20715328 | 0.82 | SMN1; SMN2 (1.00) | TRPC5TRPC4SMN1; SMN2HTTUSP2 | |
| SCHEMBL19714457 | 0.81 | TSHR (0.71) | TRPC5TRPC4SMN1; SMN2HTTUSP2 | |
| SCHEMBL1170123 | 0.76 | SMN1; SMN2 (0.74) | TRPC5TRPC4SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL1169982 | 0.75 | ALDH1A1 (0.69) | TRPC5TRPC4SMN1; SMN2HTTMAPK1 | |
| SCHEMBL28805359 | 0.73 | MAPT (0.62) | TRPC5TRPC4SMN1; SMN2HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL28745357 | 0.73 | CYP1A2 (0.66) | TRPC5TRPC4SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL1170308 | 0.72 | ALDH1A1 (0.61) | TRPC5TRPC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1170118 | 0.71 | KMT2A (0.64) | TRPC5TRPC4SMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114642744-B | Method for screening morphine-tolerance-relieving drugs | 南京医科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-114642744-A | Method for screening morphine tolerance relieving drugs | 南京医科大学 | 2022-06-21 | — | — | CN | disclosed |