Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.86 |
| ▸ | MAPT | P10636 | 1/20 | 0.86 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.73 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | ALPL | P05186 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170123 | 0.89 | SMN1; SMN2 (0.74) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 | |
| SCHEMBL1169982 | 0.88 | ALDH1A1 (0.69) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 | |
| SCHEMBL22619593 | 0.85 | TRPC5 (1.00) | ALDH1A1MAPTTRPC4TRPC5SMN1; SMN2 | |
| SCHEMBL29646286 | 0.85 | TRPC5 (1.00) | ALDH1A1MAPTTRPC4TRPC5SMN1; SMN2 | |
| SCHEMBL1170118 | 0.83 | KMT2A (0.64) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 | |
| SCHEMBL28805359 | 0.83 | MAPT (0.62) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 | |
| Hydrochloric Acid SCHEMBL28745357 | 0.83 | CYP1A2 (0.66) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 | |
| SCHEMBL30218922 | 0.82 | SMN1; SMN2 (0.64) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 | |
| SCHEMBL28972173 | 0.82 | SMN1; SMN2 (0.64) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 | |
| SCHEMBL19713871 | 0.82 | CYP1A2 (0.63) | ALDH1A1MAPTTRPC4TRPC5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103044337-A | Synthetic method of 2-(N-alkyl)aminooimidazole derivatives | UNIV NANJING SCIENCE & TECH | 2013-04-17 | — | — | CN | disclosed |
| EP-2319512-A1 | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels. | NeuroSearch AS (DK) | 2011-05-11 | — | — | EP | disclosed |
| US-20110034527-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | SOERENSEN ULRIK SVANE | 2011-02-10 | — | — | US | disclosed |
| US-7842817-B2 | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels | NEUROSEARCH A/S (DK) | 2010-11-30 | — | — | US | disclosed |
| EP-1838306-B1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH AS (DK) | 2010-11-17 | — | — | EP | disclosed |
| US-20100280087-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | SOERENSEN ULRIK SVANE | 2010-11-04 | — | — | US | disclosed |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | NEURO SEARCH A/S (DK) | 2008-08-21 | — | — | US | disclosed |
| EP-1838306-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006074991-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034527-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | KCNN2, KCNN1, KCNN3 | ALDH1A1 3979/4885MAPT 1733/4885TRPC4 77/4885 |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | KCNN2, KCNN1, KCNN3 | ALDH1A1 3979/4885MAPT 1733/4885TRPC4 77/4885 |
| US-20100280087-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | KCNN2, KCNN1, KCNN3 | ALDH1A1 3979/4885MAPT 1733/4885TRPC4 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.