Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DTYMK | P23919 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982635 | 0.96 | NR1H2 (0.40) | NR1H2TP53ESR2USP2SMN1; SMN2 | |
| SCHEMBL4390630 | 0.91 | NR1H2 (0.41) | NR1H2TP53ESR2USP2SMN1; SMN2 | |
| SCHEMBL7587617 | 0.87 | PLA2G2A (0.44) | NR1H2ESR2USP2SMN1; SMN2ADORA1 | |
| SCHEMBL24072420 | 0.87 | PLA2G2A (0.44) | NR1H2ESR2USP2SMN1; SMN2ADORA1 | |
| SCHEMBL1583540 | 0.86 | CNR2 (0.40) | NR1H2ESR2USP2SMN1; SMN2ADORA1 | |
| SCHEMBL22692273 | 0.86 | NR1H2 (0.38) | NR1H2ESR2USP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL18205300 | 0.85 | NR1H2 (0.39) | NR1H2TP53ESR2USP2SMN1; SMN2 | |
| SCHEMBL1176507 | 0.85 | NR1H2 (0.40) | NR1H2TP53ESR2USP2SMN1; SMN2 | |
| SCHEMBL12523828 | 0.84 | P2RX7 (0.43) | NR1H2TP53ESR2USP2SMN1; SMN2 | |
| SCHEMBL21520542 | 0.84 | DDB1 (0.39) | NR1H2TP53ESR2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4000623-A1 | 5-(2-(1H-INDOL-3-YL))-ETHYL)- PIPERAZIN-2-ONE DERIVATIVES FOR USE IN THE TREATMENT OF VIRAL INFECTIONS BY VIRUSES OF THE FAMILY CORONAVIRIDAE | Consejo Superior De Investigaciones Científicas (ES) | 2022-05-25 | — | — | EP | disclosed |