Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24072420 | 1.00 | PLA2G2A (0.44) | PLA2G2ACNR2TLR8NR1H2GBA1 | |
| SCHEMBL1583540 | 0.95 | CNR2 (0.40) | PLA2G2ACNR2TLR8NR1H2P2RX7 | |
| SCHEMBL1583253 | 0.89 | P2RX7 (0.46) | CNR2NR1H2P2RX7ALDH1A1ESR2 | |
| SCHEMBL22692273 | 0.88 | NR1H2 (0.38) | PLA2G2ACNR2NR1H2ALDH1A1ESR2 | |
| SCHEMBL29646565 | 0.87 | NR1H2 (0.39) | CNR2NR1H2ALDH1A1ESR2USP2 | |
| SCHEMBL18205300 | 0.85 | NR1H2 (0.39) | NR1H2ALDH1A1ESR2USP2SMN1; SMN2 | |
| SCHEMBL7982635 | 0.85 | NR1H2 (0.40) | NR1H2ALDH1A1ESR2USP2SMN1; SMN2 | |
| SCHEMBL21520542 | 0.84 | DDB1 (0.39) | NR1H2ALDH1A1ESR2USP2SMN1; SMN2 | |
| SCHEMBL12523828 | 0.84 | P2RX7 (0.43) | NR1H2P2RX7ALDH1A1ESR2USP2 | |
| SCHEMBL4005175 | 0.83 | NR1H2 (0.41) | NR1H2ALDH1A1ESR2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |