Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496262 | 1.00 | BMP1 (0.39) | BMP1CCR6MMP1MMP9MMP13 | |
| SCHEMBL24496004 | 0.91 | BMP1 (0.39) | BMP1CCR6MMP1MMP9MMP13 | |
| SCHEMBL29648328 | 0.86 | CCR6 (0.38) | BMP1CCR6MMP1MMP9MMP13 | |
| SCHEMBL24496286 | 0.86 | CCR6 (0.38) | BMP1CCR6MMP1MMP9MMP13 | |
| SCHEMBL22718255 | 0.86 | MMP1 (0.40) | BMP1CCR6MMP1MMP9MMP13 | |
| SCHEMBL29438883 | 0.86 | MMP1 (0.40) | BMP1CCR6MMP1MMP9MMP13 | |
| SCHEMBL24496289 | 0.84 | MAPK8 (0.36) | MAPTLMNAALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL29648298 | 0.84 | MAPK8 (0.36) | MAPTLMNAALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL22718251 | 0.83 | TEAD1 (0.49) | BMP1CCR6MMP1MMP9MMP13 | |
| SCHEMBL29438915 | 0.83 | TEAD1 (0.49) | BMP1CCR6MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |