Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25801783 | 0.92 | TEAD1 (0.46) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL24496068 | 0.86 | CYP19A1 (0.47) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL29648307 | 0.86 | CYP19A1 (0.47) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL29648341 | 0.84 | CYP19A1 (0.47) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL24496161 | 0.84 | CYP19A1 (0.47) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL24496072 | 0.82 | ALDH1A1 (0.46) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL24496309 | 0.82 | CYP19A1 (0.45) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL29648404 | 0.82 | CYP19A1 (0.45) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL24496144 | 0.82 | MAPT (0.43) | PTGS2CYP19A1CA2CA1CA12 | |
| SCHEMBL24496010 | 0.81 | ALDH1A1 (0.51) | CYP19A1CA2CA1CA12KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |