Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iosefamic Acid SCHEMBL29400390 | 1.00 | TSHR (0.55) | TSHRMAPK1LMNASMN1; SMN2HDAC1 | |
| Iosefamic Acid SCHEMBL38639 | 1.00 | TSHR (0.55) | TSHRMAPK1LMNASMN1; SMN2HDAC1 | |
| Iocarmic Acid SCHEMBL38580 | 0.98 | TSHR (0.56) | TSHRMAPK1LMNASMN1; SMN2HDAC1 | |
| SCHEMBL9716687 | 0.86 | TSHR (0.52) | TSHRMAPK1LMNASMN1; SMN2HDAC1 | |
| SCHEMBL30881052 | 0.85 | LMNA (0.42) | TSHRMAPK1LMNASMN1; SMN2KDM4E | |
| SCHEMBL8610051 | 0.85 | LMNA (0.42) | TSHRMAPK1LMNASMN1; SMN2 | |
| SCHEMBL11632856 | 0.84 | MAPK1 (0.46) | TSHRMAPK1SMN1; SMN2ALDH1A1 | |
| Iocarmic Acid SCHEMBL29886627 | 0.83 | SMN1; SMN2 (0.65) | TSHRMAPK1LMNASMN1; SMN2KDM4E | |
| SCHEMBL3833534 | 0.82 | LMNA (0.40) | TSHRMAPK1LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL11406813 | 0.81 | LMNA (0.47) | TSHRMAPK1LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124889-A1 | COMPOSITIONS AND METHODS FOR THE VECTORED AUGMENTATION OF PROTEIN DESTRUCTION, EXPRESSION AND/OR REGULATION | VOYAGER THERAPEUTICS, INC. | 2024-04-18 | — | — | US | disclosed |
| US-20220389449-A1 | COMPOSITIONS FOR THE TREATMENT OF DISEASE | VOYAGER THERAPEUTICS, INC. | 2022-12-08 | — | — | US | disclosed |
| US-11326182-B2 | Compositions for the treatment of disease | VOYAGER THERAPEUTICS, INC. (US) | 2022-05-10 | — | — | US | disclosed |