SCHEMBL3833534

SCHEMBL3833534

CNC(=O)c1c(I)c(NC(=O)CN(CC(=O)Nc2c(I)c(C(=O)O)c(I)c(C(=O)NC)c2I)CC(=O)Nc2c(I)c(C(=O)O)c(I)c(C(=O)NC)c2I)c(I)c(C(=O)O)c1I

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.40
TSHR P16473 3/20 0.38
MAPK1 P28482 2/20 0.38
ALOX15 P16050 1/20 0.38
CYP2C19 P33261 1/20 0.38
HIF1A Q16665 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
DRD3 P35462 1/20 0.35
MAPT P10636 2/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP3A4 P08684 1/20 0.34
MC4R P32245 1/20 0.34
SCN4A P35499 1/20 0.34
MC3R P41968 1/20 0.34
HTR3A P46098 1/20 0.34
SCN5A Q14524 1/20 0.34
SCN9A Q15858 1/20 0.34
SCN3A Q9NY46 1/20 0.34
HPGD P15428 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30881052 0.85 LMNA (0.42) LMNATSHRMAPK1SMN1; SMN2MAPT
SCHEMBL8610051 0.85 LMNA (0.42) LMNATSHRMAPK1SMN1; SMN2CA1
Iocarmic Acid SCHEMBL38580 0.84 TSHR (0.56) LMNATSHRMAPK1SMN1; SMN2CYP3A4
Iosefamic Acid SCHEMBL29400390 0.82 TSHR (0.55) LMNATSHRMAPK1SMN1; SMN2ALDH1A1
Iosefamic Acid SCHEMBL29648519 0.82 TSHR (0.55) LMNATSHRMAPK1SMN1; SMN2ALDH1A1
Iosefamic Acid SCHEMBL38639 0.82 TSHR (0.55) LMNATSHRMAPK1SMN1; SMN2ALDH1A1
SCHEMBL11406813 0.81 LMNA (0.47) LMNATSHRMAPK1CYP2C19SMN1; SMN2
Iothalamic Acid SCHEMBL29746594 0.80 LMNA (0.56) LMNATSHRMAPK1SMN1; SMN2
Iothalamic Acid SCHEMBL38419 0.80 LMNA (0.56) LMNATSHRMAPK1SMN1; SMN2
SCHEMBL11292715 0.79 LMNA (0.36) LMNATSHRMAPK1ALOX15SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2125054-A2 PARTIALLY BIOABSORBABLE IMPLANT CINVENTION AG (DE) 2009-12-02 EP disclosed
EP-2120807-A2 DEGRADABLE RESERVOIR IMPLANTS CINVENTION AG (DE) 2009-11-25 EP disclosed
EP-2117613-A1 CARBON STENTS CINVENTION AG (DE) 2009-11-18 EP disclosed
EP-2111482-A2 MEDICAL DEVICES WITH EXTENDED OR MULTIPLE RESERVOIRS CINVENTION AG (DE) 2009-10-28 EP disclosed
EP-2104472-A1 POROUS, DEGRADABLE IMPLANT MADE BY POWDER MOLDING CINVENTION AG (DE) 2009-09-30 EP disclosed
EP-2104473-A1 POROUS, NON-DEGRADABLE IMPLANT MADE BY POWDER MOLDING CINVENTION AG (DE) 2009-09-30 EP disclosed
US-20090192592-A1 POROUS IMPLANT STRUCTURE CINVENTION AG (DE) 2009-07-30 US disclosed
WO-2008122594-A2 PARTIALLY BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE AND CARTILAGE REPAIR CINVENTION AG (DE) 2008-10-16 WO disclosed
WO-2008122596-A2 CURABLE THERAPEUTIC IMPLANT COMPOSITION CINVENTION AG (DE) 2008-10-16 WO disclosed
WO-2008122595-A2 BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE OR CARTILAGE REPAIR CINVENTION AG (DE) 2008-10-16 WO disclosed
WO-2008087213-A1 POROUS, DEGRADABLE IMPLANT MADE BY POWDER MOLDING CINVENTION AG (DE) 2008-07-24 WO disclosed
EP-1830902-A2 COMBINATION COMPRISING AN AGENT PROVIDING A SIGNAL, AN IMPLANT MATERIAL AND A DRUG CINVENTION AG (DE) 2007-09-12 EP disclosed
US-20060177379-A1 Composition comprising an agent providing a signal, an implant material and a drug CINVENTION AG (DE) 2006-08-10 US disclosed
WO-2006069677-A2 COMBINATION COMPRISING AN AGENT PROVIDING A SIGNAL, AN IMPLANT MATERIAL AND A DRUG CINVENTION AG (DE) 2006-07-06 WO disclosed
US-20020159951-A1 Novel targeted compositions for diagnostic and therapeutic use IMARX THERAPEUTICS, INC. 2002-10-31 US disclosed
US-5346690-A Composition of a superparamagnetic or ferromagnetic particle and an X-ray contrast agent for MRI NYCOMED IMAGING AS (NO) 1994-09-13 US disclosed
EP-0414288-B1 Contrast media NYCOMED IMAGING AS (NO) 1994-03-23 EP disclosed
EP-0414287-B1 Particulate contrast media NYCOMED IMAGING AS (NO) 1994-01-19 EP disclosed
EP-0473729-A1 CONTRAST MEDIA NYCOMED AS (NO) 1992-03-11 EP disclosed
WO-1991001149-A1 CONTRAST MEDIA NYCOMED AS (NO) 1991-02-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020159951-A1 Novel targeted compositions for diagnostic and therapeutic use FABP3, SELPLG, ASGR1 LMNA 589/4885TSHR 999/4885MAPK1 4304/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.