Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCD | Q05655 | 9/20 | 0.51 |
| ▸ | PRKCH | P24723 | 8/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 8/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.51 |
| ▸ | LATS1 | O95835 | 1/20 | 0.47 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 4/20 | 0.40 |
| ▸ | PRKCB | P05771 | 3/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324615 | 1.00 | PRKCD (0.51) | PRKCDPRKCHPRKCEPRKCQLATS1 | |
| SCHEMBL30855724 | 0.79 | IMPDH2 (0.44) | PRKCDPRKCHPRKCEPRKCQPIM1 | |
| SCHEMBL21201370 | 0.79 | IMPDH2 (0.44) | PRKCDPRKCHPRKCEPRKCQPIM1 | |
| SCHEMBL3326564 | 0.78 | PRKCH (0.55) | PRKCDPRKCHPRKCEPRKCQLATS1 | |
| SCHEMBL15488451 | 0.77 | IMPDH2 (0.43) | PIM1HASPINCCNT1CDK9LMNA | |
| SCHEMBL3327006 | 0.74 | PRKCD (0.56) | PRKCDPRKCHPRKCEPRKCQLATS1 | |
| SCHEMBL3713151 | 0.74 | MAPK10 (0.48) | PIM1HASPINCCNT1CDK9PRKCZ | |
| SCHEMBL21917154 | 0.73 | CHUK (0.44) | PIM1HASPINCCNT1CDK9IMPDH2 | |
| SCHEMBL23301129 | 0.72 | PRKCZ (0.43) | PRKCDPRKCHPRKCEPRKCQPIM1 | |
| SCHEMBL23328129 | 0.72 | PDE2A (0.40) | PRKCDPRKCHPRKCEPRKCQPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621222-B | 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-110573511-B | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114621222-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-06-14 | — | — | CN | disclosed |