Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721376 | 0.80 | GRM5 (0.40) | CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL2431769 | 0.78 | CHRNB2 (0.51) | HPGDCYP11B1CYP11B2CYP17A1NCOA3 | |
| SCHEMBL17691566 | 0.78 | MAPK10 (0.49) | MAPK10TNFCYP19A1KDM4EHTT | |
| SCHEMBL16231499 | 0.76 | CRHBP (0.54) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL30647528 | 0.76 | CRHBP (0.54) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL9825900 | 0.75 | TNF (0.73) | MAPK10TNFCYP19A1KDM4EHTT | |
| SCHEMBL3714670 | 0.75 | KDM4E (0.45) | MAPK10CYP19A1KDM4EHTTNPC1 | |
| SCHEMBL23935177 | 0.74 | MAPK10 (0.69) | MAPK10TNFCYP19A1KDM4EHTT | |
| SCHEMBL29650673 | 0.74 | PRKCD (0.51) | MAPTPRKCZPRKD2HASPINCCNT1 | |
| SCHEMBL3324615 | 0.74 | PRKCD (0.51) | MAPTPRKCZPRKD2HASPINCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |